Subclinical isolation of Epstein—Barr viruses and immunity in women with genital herpes

Abstract

The aim of the study was to study the incidence of asymptomatic determination of Epstein-Barr viruses (EBV) in women with genital herpes (GH) with a recurring course of the disease depending on the stage of the process of infection and the state of vaginal microbiota. It was shown that, in the case of a severe course of GH, this phenomenon is observed both with recurrence of the disease (28 % of cases) and remission (18 % of cases). This is facilitated by the immune response that forms in patients with Th2 type. With an average course of GH during remission, but against a background of bacterial vaginosis (BV), VEB is isolated in 23 % of cases, and after its treatment in 8 %. This is explained by the Th2 type of immune response, and the lack of local antiviral immunity in BV. It was shown that a decrease in the intensity of the local and general antiviral immune response is able to “include” the mechanism of asymptomatic VEB secretion. Refs 23. Figs 6. Tables 2.