The role of central nervous system in the regulation of cell division process and of radiosensitivity of chromosomes of corneal epithelial cells in mice

Abstract

It is well known that the influence of stress factors on mitosis occurs by means of reactive inhibition of the beginning of cell division. This inhibition is reflective in its nature. The role of central nervous system in the regulation of cell division process as well as radiosensitivity of chromosomes is considered in the article. The study is performed with the males of CC57W stock of mice using the method of conditioned reflex. The effect of each of combined stimuli (conditioned and unconditioned) has been studied and punishment stimulation has been included into stereotype. Both conditioned and unconditioned stimuli after the formation of conditioned reflex (after 63 combinations) determine significant decrease of mitotic index in corneal epithelium. Punishment stimulation (in 142 combinations) did not give such an effect. Conditioned and unconditioned stimuli applied in two hours after irradiation of an experimental animal with X-rays (100 r) caused the decrease of the level of chromosomal aberrations in cells fixed in 24 hour after irradiation. It is suggested that cell division process and the formation of induced chromosomal aberrations are under control of central nervous system.