Condensation of substituted benzaldehydes with benzyl chloromethyl ether at the phase transfer catalysis

Abstract

Condensation of chloromethyl benzyl ether with arylaldehydes and sodium hydroxide in conditions of phase transfer catalysis (the catalyst — TEBACl) is investigated. The method of synthesis 2-benzyloxy-3-aryloxiranes (10 examples) is developed. The synthesis oxiranes undergoes stereoselectively with formation a trans-isomers. Refs 5.