Poly(2-deoxy-2-methacrylamido-Dglucose) copolymer modified by cyclodextrin

Abstract

The solution properties of novel synthetic biocompatible polymers have been investigated. Copolymers of 2-deoxy-2-methacrylamido-D-glucose with acrylic acid modified by β-cyclodextrin (MAG—AA—CD) or cholesterol (MAG—AA—Chol) were the objects of the study by the methods of viscometry, refractometry and dynamic light scattering in 0.2M NaCl. Such macromolecular parameters as translation diffusion coefficient D, hydrodynamic radius Rh, and intrinsic viscosity value [η] were determined. Also there were analyzed the conditions for complex formation between MAG—AK—CD and MAG—AA—Chol. After obtaining experimental data the results have shown that it demands specific condition of complex formation, suitable for the study of dynamic light scattering. Refs 7. Figs 3. Tables 2.