The interrelation of interleukin-6 and characteristics of cardiorenal anemia syndrome in diabetic nephropathy

Abstract

Diabetic nephropathy is a common complication of diabetes mellitus with a negative prognostic value. Currently, there are no doubts that infl ammation has a pathogenic role not only in the development of diabetic kidney disease but in the formation of all of the characteristics of cardiorenal anemia syndrome. The aim of the study was to assess the clinical significance of interleukin-6 evaluation in patients with diabetic nephropathy. We investigated 127 patients with type 2 diabetes mellitus complicated with chronic kidney disease stages 1–3. The results of the study indicate that serum concentration of interleukin-6 correlates negatively with hemoglobin level and estimated glomerular filtration rate. Meanwhile, it has no clear relationship with age, sex, treatment modality, body mass index, urinary albumin excretion and echocardiography data. In this paper we discuss the causes and the effects of elevated interleukin-6 production in patients with diabetic nephropathy. Further avenues of research are proposed. Refs 25. Figs 1. Table 2.