Genotype combinations analysis by truncate wald’s method to estimate the disease risk

Abstract

On basis of candidate genes genotypes choice a method is proposed to reveal the susceptibility to disease. The procedure of decision on a patient belonging to risk group is described. An algorithm of heterogeneity degree evaluation for the tables containing information on genotypes of risk and control groups is considered. Some calculation restrictions of the method and possibilities of its modification for large tables are pointed to. Refs 9. Fig. 1.