Hepatorenal syndrome in patients with cirrhosis
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Abstract
Гепаторенальный синдром - осложнение, которое представляет собой прогрессирующую почечную недостаточность, развивающуюся на фоне цирроза печени. Жизненный прогноз при данной патологии - крайне неблагоприятный. В связи с этим было проведено исследование для того, чтобы:
1.Выявить особенности клинической симптоматики ЦП различной этиологии у пациентов с ГРС и без него.
2.Выявить особенности изменения лабораторных показателей у исследуемых пациентов.
3.Выявить особенности инструментальной диагностики у исследуемых пациентов.
Общее количество исследуемых больных составило 100, из них в исследование включены 50 пациентов с цирротической стадией хронического гепатита различной этиологии, имеющих наиболее полное клиническое, лабораторное и инструментальное обследование. Наблюдаемые пациенты распределены на две группы наблюдения. Первая группа представлена 30 пациентами с диагностированным гепаторенальным синдромом, вторая группа – 20 пациентами, у которых признаки гепаторенального синдрома отсутствуют.
На основании полученных данных нами сделаны следующие выводы:
1. 1. Из обследованных 100 пациентов примерно в трети случаев цирроз печени осложняется присоединением гепаторенального синдрома.
2. У пациентов с гепаторенальным синдромом, возникшем на фоне цирроза печени достоверно чаще наблюдается и более выражен диспепсический синдром.
3. Развитие почечной недостаточности при ГРС у больных циррозом печени сопровождается нарастанием анемии, синдромов желтухи, холестаза, гепатодепрессии, портальной гипертензии.
Hepatorenal syndrome is a complication that is a progressive renal failure that develops on the background of liver cirrhosis. The life prognosis for this pathology is extremely unfavorable. In this regard, a study was conducted in order to: 1. Identify the features of the clinical symptoms of CP of various etiologies in patients with and without HRS. 2. Identify the features of changes in laboratory parameters in the studied patients. 3. To reveal the features of instrumental diagnostics in the studied patients. The total number of studied patients was 100, of which 50 patients with a cirrhotic stage of chronic hepatitis of various etiology and having the most complete clinical, laboratory and instrumental examination were included in the study. Observed patients are divided into two groups of observation. The first group is represented by 30 patients diagnosed with hepatorenal syndrome, the second group - by 20 patients with no signs of hepatorenal syndrome. Based on the data obtained, we made the following conclusions: 1. 1. Of the 100 patients examined, approximately one third of cases of cirrhosis of the liver is complicated by the addition of hepatorenal syndrome. 2. In patients with hepatorenal syndrome, which arose on the background of cirrhosis of the liver, dyspeptic syndrome is more often observed and more pronounced. 3. The development of renal failure in the GDS in patients with liver cirrhosis is accompanied by an increase in anemia, jaundice syndromes, cholestasis, hepatodepression, portal hypertension.
Hepatorenal syndrome is a complication that is a progressive renal failure that develops on the background of liver cirrhosis. The life prognosis for this pathology is extremely unfavorable. In this regard, a study was conducted in order to: 1. Identify the features of the clinical symptoms of CP of various etiologies in patients with and without HRS. 2. Identify the features of changes in laboratory parameters in the studied patients. 3. To reveal the features of instrumental diagnostics in the studied patients. The total number of studied patients was 100, of which 50 patients with a cirrhotic stage of chronic hepatitis of various etiology and having the most complete clinical, laboratory and instrumental examination were included in the study. Observed patients are divided into two groups of observation. The first group is represented by 30 patients diagnosed with hepatorenal syndrome, the second group - by 20 patients with no signs of hepatorenal syndrome. Based on the data obtained, we made the following conclusions: 1. 1. Of the 100 patients examined, approximately one third of cases of cirrhosis of the liver is complicated by the addition of hepatorenal syndrome. 2. In patients with hepatorenal syndrome, which arose on the background of cirrhosis of the liver, dyspeptic syndrome is more often observed and more pronounced. 3. The development of renal failure in the GDS in patients with liver cirrhosis is accompanied by an increase in anemia, jaundice syndromes, cholestasis, hepatodepression, portal hypertension.