Adipose derived stem cells transplantation negative effects (review)

Abstract

The data here represents those of specialists in plastic, reconstructive and aesthetic surgery who investigated the risks of development and structure of cell therapy-associated complications, both at the stage of collecting biological material for stem cells (SC) isolation and their subsequent transplantation. Data analysis suggests that even in minimally invasive surgical procedures during cell-associated lipotransfer (CAL), these surgeries are still fraught with risks of complications even in cases of somatically healthy patients for aesthetic indications. The incidence of life-threatening complications of CAL varies from 0.02% to 0.3%. It is clear that CAL-surgery must be carried out exclusively on the testimony based on the data of clinical examination of patients before SC transplantation. To prevent CAL complications in the postoperative period, the rules of aseptic and antiseptic, comprehensive thrombotic events prevention (irrespective of surgery), targeted compensatory adjustment of concomitant pathology of the patient must be scrupulously observed. Refs 70.