Архив открытого доступаСанкт-Петербургского государственного университета
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http://hdl.handle.net/11701/8631Полная запись метаданных
| Поле DC | Значение | Язык |
|---|---|---|
| dc.contributor.author | Orlova, O. I. | - |
| dc.contributor.author | Karakashev, G. V. | - |
| dc.contributor.author | Shmurak, V. I. | - |
| dc.contributor.author | Abzianidze, V. V. | - |
| dc.contributor.author | Savelieva, E. I. | - |
| dc.date.accessioned | 2017-10-28T15:20:42Z | - |
| dc.date.available | 2017-10-28T15:20:42Z | - |
| dc.date.issued | 2017-09 | - |
| dc.identifier.citation | Orlova O. I., KarakashevG.V., ShmurakV. I., AbzianidzeV.V., Savelieva E. I. Determination of N7-[2-[(2-hydroxyethyl)thio]-ethyl]guanine in rat’s urine as biomarker of exposure of sulfur mustard. Vestnik SPbSU. Physics and Chemistry. 2017. Vol. 4 (62), iss. 3. P. 313–325. | en_GB |
| dc.identifier.other | 10.21638/11701/spbu04.2017.306 | - |
| dc.identifier.uri | http://hdl.handle.net/11701/8631 | - |
| dc.description.abstract | A method for the determination of the sulfur mustard (SM) exposure biomarker-N7-[2-[(2-hydroxyethyl) thio]-ethyl]guanine (N7-HETEG) byhigh-performance liquid chromatography-positive electrospray tandem mass spectrometry (HPLC-ESI-MS/MS) was developed. An analytical standard of N7-HETEG was synthesized and purified ( 90%). The limit of detection of the developed method is1 ng/mL. The method was linearly calibrated from 1 ng/mL to 100 ng/mL.The method was further applied for the quantifications of N7-HETEG in rat urine exposed of SM in vivo at dosage of 2 mg/kg. Refs 13. Figs 10. Tables 1. | en_GB |
| dc.language.iso | ru | en_GB |
| dc.publisher | St Petersburg State University | en_GB |
| dc.relation.ispartofseries | Vestnik of St Petersburg University. Physics and Chemistry;Vol. 4 (62); Issue 3 | - |
| dc.subject | sulfurmustard | en_GB |
| dc.subject | biomedical samples | en_GB |
| dc.subject | biomarker | en_GB |
| dc.subject | metabolite | en_GB |
| dc.subject | adduct | en_GB |
| dc.subject | DNA | en_GB |
| dc.subject | highperformance liquid chromatography | en_GB |
| dc.title | Determination of N7-[2-[(2-hydroxyethyl)thio]-ethyl]guanine in rat’s urine as biomarker of exposure of sulfur mustard | en_GB |
| dc.type | Article | en_GB |
| Располагается в коллекциях: | Issue 3 | |
Файлы этого ресурса:
| Файл | Описание | Размер | Формат | |
|---|---|---|---|---|
| 06-Orlova.pdf | 504,73 kB | Adobe PDF | Просмотреть/Открыть |
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