Interrelation of reduction of mismatch negativity and cognitive deficit in paranoid schizophrenia

Abstract

This study shows a relationship between the reduction of mismatch negativity (MMN) and the structure and severity of cognitive deficits in patients with paranoid schizophrenia. The study involved 19 patients with paranoid schizophrenia and 43 healthy subjects. The results of BACS and the psychophysiological research method of event related potentials (ERPs) found a relationship between the reduction of MMN and limited verbal working memory, reduced information processing speed and verbal fluency in patients with paranoid schizophrenia. The findings support the hypothesis posed about the importance of early information processing on the formation of cognitive deficits in patients with paranoid schizophrenia patients. Refs 36. Figs 3. Tables 2.