Creatine kinase in periprocedural myocardial injury after percutaneous coronary intervention

Abstract

Patients with ischemic heart disease undergoing percutaneous coronary intervention are characterized by various degrees of myocardial damage. The purpose of the study is to investigate the dependence of micro-injuries of the myocardium on the nature of the damage to the coronary arteries and the features of the procedure during the interventional treatment in patients with stable angina. Myocardial damage was diagnosed based on the dynamics of cardiospecific biomarkers of creatine kinase-myocardial band isoenzyme before and 24 hours after intervention. Providing the analysis of the phenomenon in the totality of its characteristics, the use of multivariate statistics (principal component method, stepwise discriminant analysis) allowed not only to differentiate patients with or without periprocedural myocardial damage and to determine the possibility of their differentiation by the impacts of such characteristics as “the total number of inflations” and “total number of affected arteries”, but also to point out a level of creatine kinase before intervention as a sign of potential vulnerability/resistance of myocardium. The latter can be considered as a separate component characterizing the state of cardiomyocytes and the degree of risk of postprocedural myocardial damage. Thus, investigation of nature of the complication is important not only for its prevention but for study the whole cardioprotection issue. Refs 26. Figs 2. Tables 7.