The influence of mucoactive agents on the state of non-specific proteinases and their inhibitors in patients with acute catarrhal rhinosinusitis

Abstract

The study was conducted in three groups of patients (45 subjects) with acute catarrhal rhinosinusitis using mucoactive agents as a part of treatment. It has been established that this pathology is characterized by an acute-phase increase of antitrypsin activity in the blood serum and sinonasal discharge. Comparative analysis of the results obtained aft er applying various groups of mucoactive agents has demonstrated that BNO-101 has greater effect in this type of infl ammation; it decreased the activity of elastase and trypsin-like proteases while normalizing clinical symptoms and the activity of proteinase inhibitors in the sinonasal discharge. Refs 12. Table 1.