Analysis of survival parameters of patients with hematological malignancies in Saint Petersburg at the population level

Abstract

This article presents an analysis of changing parameters of cumulative 5-year survival, corrected and relative survival of patients with various hematological malignancies in Saint-Petersburg with the population divided in relation to sex, age, and the time of diagnosis (for 1996–1999, 2000–2003 and 2004–2007). The study was conducted according to the database of the Population Cancer Register (PCR) of Saint-Petersburg. Parameters were calculated with the actuarial method using the PCR software complex. Positive survival changes were noted in patients with Hodgkins lymphoma, multiple myeloma, acute lymphoblastic leukemia (<18 years-old group (y. o.)), chronic lymphoid leukemia, chronic myeloid leukemia (<60 y. o.); negative changes were observed in acute myeloid leukemia, acute lymphoblastic leukemia (≥18 y. o.), chronic myeloid leukemia (≥60 y. o.). Male survival was lower in the majority of hematological malignancies compared to female survival. Positive survival changes indicate the efficacy of the programmed treatment of hematological malignancies. The most striking increase of patient survival was noted for those diagnosed in years 2004–2007, which may be explained by the use of highly efficient target drugs of the latest generations. Patients’ age had the most significant impact on survival parameters. Refs 8. Tables 8.