Effect of Sodium Fumarate for Blood Oxidant and Antioxidant Activity of Patients with Traumatic Shock

Abstract

In instances when patients with traumatic shock enter anti-shock treatments a marked increase in indicators of oxidative activity is observed as spontaneous and induced chemiluminescence against a background of a strong reduction of total antioxidant activity of the blood. This confirms the development of oxidative stress in the first hours of shock trauma. Sodium fumarate increases antioxidant activity and, consequently, decreases oxidant activity of blood of patients with traumatic shock, resulting in a general improvement of the сlinical state. The inclusion of sodium fumarate in the complex therapy of patients with traumatic shock led to a decrease in the severity of multiple organ dysfunction and, as a consequence, reduction of stay in the intensive care unit. Refs 10. Tables 4.