Factor analysis of leptin, adiponectin effect and resistin during bronchial asthma

Abstract

To date, the participation of particular adipokines (leptin, adiponectin, resistin) in the pathogenesis of bronchial asthma has been well studied, however, their interaction, in particular their cooperative effect on the course of the disease, has not been practically studied. The aim of the study is to identify the effect of the cooperative interaction of key adipokines on the course of bronchial asthma, depending on the pathogenetic variant of the disease. Factor analysis was used to analyze the data from the study of the levels of leptin, adiponectin, resistin in 56 patients with bronchial asthma. Factor analysis made it possible to identify 3 factors. Factor 1 reflects the direct effect of leptin signaling on the severity of bronchial asthma, to a lesser extent on the exacerbation of the disease. In this case, the adiponectin component, with a high negative factor load, is associated with the severity of the course and the phase of bronchial asthma. Factor 2 reflects the direct effect of another adipokine resistin on the severity of bronchial asthma, but we draw attention to the fact that the resistin component with a large positive factor loading is associated with a non-allergic variant of bronchial asthma and exacerbation of the disease. Factor analysis revealed a fundamentally different pathogenetic role in relation to the severity of bronchial asthma of such adipokines as leptin and resistin in different variants of the disease.