Regenerative therapy by tissue-protective cytokines as a component of bacterial cellulose based wound dressings

Abstract

In experiments on rats we have conducted a comparative evaluation of effectiveness of tissue-protective cytokines application (erythropoietin, ARA 290) per se and combined with antiseptic agent (dioxydine) as components of wound dressings based on Gluconacetobacter xylinus cellulose using third degree contact thermal injury model and residual thermal injury model. We’ve determined an optimal sorption time of peptide solutions by gel films — 24 hours. We also show that local application of such wound dressings optimises wound process, reduces treatment time of granulating wounds during entire wound process, and mitigates risk of necessity for skin grafting or at least provides proper preparation of a wound to skin grafting. Refs 20. Figs 3. Таbles 2.