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http://hdl.handle.net/11701/16647
Полная запись метаданных
Поле DC | Значение | Язык |
---|---|---|
dc.contributor.author | Shilov, Viktor V. | - |
dc.contributor.author | Yudin, Mikhail A. | - |
dc.contributor.author | Vengerovich, Nikolai G. | - |
dc.contributor.author | Shcherbakov, Taras V. | - |
dc.contributor.author | Bogacheva, Aleksandra S. | - |
dc.date.accessioned | 2019-11-26T12:36:06Z | - |
dc.date.available | 2019-11-26T12:36:06Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | Shilov V. V., Yudin M. A., Vengerovich N. G., Shcherbakov T. V., Bogacheva A. S. Bioavailability Study of Recombinant Plasmid DNA Nerve Growth Factor after Intramuscular Injection by Electroporation. Vestnik of Saint Petersburg University. Medicine, 2019, vol. 14, issue 1, pp. 89– 97. | en_GB |
dc.identifier.other | https://doi.org/10.21638/spbu11.2019.201 | - |
dc.identifier.uri | http://hdl.handle.net/11701/16647 | - |
dc.description.abstract | Comparative analysis of plasmid DNA delivery into cells efficiency (with effective agent concentration 250 μg/kg), ensuring accumulation of nerve growth factor (NGF) after intramuscular injection and intramuscular administration using electroporation method on rats was performed. Application of electroporation method ensured over 4 times increase of DNA plasmid concentration in muscle tissue within the first hour after its injection and increased the duration of its determination. Higher bioavailability parameters were confirmed by 3 times increase in gene expression level, encoding NGF accumulation and 3 times increase in concentration of the target NGF protein in blood plasma. The results obtained allow us to recommend this method for introduction of NGF plDNA in its biological activity and effectiveness in models of nerve damage investigation. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | St Petersburg State University | en_GB |
dc.relation.ispartofseries | Vestnik of St Petersburg University. Medicine;Volume 14; Issue 2 | - |
dc.subject | plasmid DNA | en_GB |
dc.subject | pharmacokinetics | en_GB |
dc.subject | gene expression | en_GB |
dc.subject | bioavailability | en_GB |
dc.subject | electroporation | en_GB |
dc.title | Bioavailability Study of Recombinant Plasmid DNA Nerve Growth Factor after Intramuscular Injection by Electroporation | en_GB |
dc.type | Article | en_GB |
Располагается в коллекциях: | Issue 2 |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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89-97.pdf | 740,3 kB | Adobe PDF | Просмотреть/Открыть |
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