The role of serum factors in pathogenesis and clinical manifestations of CNS disorders in Hasimoto’s thyroiditis
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Работа посвящена изучению ряда иммуноэндокринных параметров у пациентов с аутоиммунным тироидитом, а также их связи с нарушениями со стороны центральной нервной системы. В исследование были включены 58 пациентов, которые были разделены на 3 клинические группы: группа пациентов, имеющих психиатрическое расстройство в сочетании с АИТ (N=17), группа пациентов с АИТ без психиатрических расстройств в состоянии эутироза или гипотироза (N=21), контрольная группа здоровых доноров (N=20). Были использованы лабораторные методы исследования (ИФА), а также инструментальные методы (УЗИ щитовидной железы). В результате исследования были сделаны выводы о достоверных связях данных лабораторно-инструментальных исследований и клинических проявлениях нарушений со стороны центральной нервной системы. А именно: 1. Выявлена связь (p<0.05) между психиатрическими симптомами (фобии, раздражительность, дефицит внимания) и пониженным уровнем FT4. 2. Выявлена связь (p<0.05) между психиатрическими симптомами (бред и генерализованная тревога) и повышенным уровнем ТТГ. 3. Выявлена связь (p<0.05) между психиатрическими симптомами (панические атаки, бред, генерализованная тревога) и повышенным уровнем пролактина. 4. Выявлена связь (p <0.05) между психиатрическими симптомами (бред, генерализованная тревога и дефицит внимания) и увеличенным объемом щитовидной железы. 5. Выявлена связь (p<0.05) между симптомом гипотироза (сухость локтей) и пониженным уровнем FT3. 6. Выявлена связь (p <0.05) между симптомом гипотироза (снижение коленных рефлексов) и повышенным уровнем АТ к ТГ. 7. Выявлена связь (p <0.05) между симптомами гипотироза (снижение коленных рефлексов, сухость локтей) и повышенным уровнем АТ к ТПО. 8. Выявлена связь (p<0.05) между увеличенным объемом щитовидной железы и повышенным уровнем АТ к ТПО.
The work is devoted to the study of a number of immunoendocrine parameters in patients with autoimmune thyroiditis, as well as their association with central nervous system disorders. The study included 58 patients who were divided into 3 clinical groups: a group of patients with psychiatric disorder in combination with AIT (N=17), a group of patients with AIT without psychiatric disorders in a condition of euthyrosis or hypothyrosis (N=21), and a control group of healthy donors (N=20). Laboratory methods of investigation (ELISA), as well as instrumental methods (ultrasound of the thyroid gland) were used. As a result of the study, there were found reliable links between laboratory-instrumental parameters and clinical manifestations of the central nervous system disorders. 1. A relationship (p <0.05) between psychiatric symptoms (phobia, irritability, attention deficit) and a decreased level of FT4 was found. 2. A relationship (p <0.05) between psychiatric symptoms (delirium and generalized anxiety) and elevated TSH level was revealed. 3. A relationship (p <0.05) between psychiatric symptoms (panic attacks, delirium, generalized anxiety) and elevated prolactin level has been identified. 4. A relationship (p <0.05) between psychiatric symptoms (delirium, generalized anxiety and attention deficit) and an increased volume of the thyroid gland was revealed. 5. A relationship (p <0.05) was found between the symptom of hypothyrosis (dryness of elbows) and a decreased level of FT3. 6. A relationship (p <0.05) between the symptom of hypothyrosis (decreased knee reflexes) and increased level of AT to TG was found. 7. The relationship (p <0.05) between symptoms of hypothyrosis (decreased knee reflexes, dryness of elbows) and increased level of AT to TPO was revealed. 8. The relationship (p <0.05) between the increased volume of the thyroid gland and the increased level of AT to TPO was identified.
The work is devoted to the study of a number of immunoendocrine parameters in patients with autoimmune thyroiditis, as well as their association with central nervous system disorders. The study included 58 patients who were divided into 3 clinical groups: a group of patients with psychiatric disorder in combination with AIT (N=17), a group of patients with AIT without psychiatric disorders in a condition of euthyrosis or hypothyrosis (N=21), and a control group of healthy donors (N=20). Laboratory methods of investigation (ELISA), as well as instrumental methods (ultrasound of the thyroid gland) were used. As a result of the study, there were found reliable links between laboratory-instrumental parameters and clinical manifestations of the central nervous system disorders. 1. A relationship (p <0.05) between psychiatric symptoms (phobia, irritability, attention deficit) and a decreased level of FT4 was found. 2. A relationship (p <0.05) between psychiatric symptoms (delirium and generalized anxiety) and elevated TSH level was revealed. 3. A relationship (p <0.05) between psychiatric symptoms (panic attacks, delirium, generalized anxiety) and elevated prolactin level has been identified. 4. A relationship (p <0.05) between psychiatric symptoms (delirium, generalized anxiety and attention deficit) and an increased volume of the thyroid gland was revealed. 5. A relationship (p <0.05) was found between the symptom of hypothyrosis (dryness of elbows) and a decreased level of FT3. 6. A relationship (p <0.05) between the symptom of hypothyrosis (decreased knee reflexes) and increased level of AT to TG was found. 7. The relationship (p <0.05) between symptoms of hypothyrosis (decreased knee reflexes, dryness of elbows) and increased level of AT to TPO was revealed. 8. The relationship (p <0.05) between the increased volume of the thyroid gland and the increased level of AT to TPO was identified.