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http://hdl.handle.net/11701/10277
Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Desheva, Yulia | - |
dc.contributor.author | Sychev, Ivan | - |
dc.contributor.author | Smolonogina, Tatiana | - |
dc.contributor.author | Rekstin, Andrey | - |
dc.contributor.author | Ilyushina, Natalia | - |
dc.contributor.author | Lugovtsev, Vladimir | - |
dc.contributor.author | Samsonova, Anastasia | - |
dc.contributor.author | Go, Aleksey | - |
dc.contributor.author | Lerner, Anna | - |
dc.date.accessioned | 2018-06-19T19:54:47Z | - |
dc.date.available | 2018-06-19T19:54:47Z | - |
dc.date.issued | 2018-05-09 | - |
dc.identifier.citation | 2,86 | en_GB |
dc.identifier.other | eISSN 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/11701/10277 | - |
dc.description.abstract | The main objective of the study was to evaluate neuraminidase inhibiting (NI) antibodies against A/H1N1pdm09 influenza viruses in the community as a whole and after infection. We evaluated NI serum antibodies against A/California/07/09(H1N1)pdm and A/South Africa/3626/2013(H1N1)pdm in 134 blood donors of different ages using enzyme-linked lectin assay and in 15 paired sera from convalescents with laboratory confirmed influenza. The neuraminidase (NA) proteins of both A/H1N1pdm09 viruses had minimal genetic divergence, but demonstrated different enzymatic and antigenic properties. 5.2% of individuals had NI antibody titers 1:20 against A/South Africa/3626/2013(H1N1)pdm compared to 53% of those who were positive to A/California/07/2009(H1N1)pdm NA. 2% of individuals had detectable NI titers against A/South Africa/3626/13(H1N1)pdm and 47.3% were positive to A/California/07/2009(H1N1)pdm NA among participants negative to hemagglutinin (HA) of A/H1N1pdm09 but positive to seasonal A/H1N1. The lowest NI antibody levels to both A/H1N1pdm09 viruses were detected in individuals born between 1956 and 1968. Our data suggest that NI antibodies against A/South Africa/3626/13 (H1N1)pdm found in the blood donors could have resulted from direct infection with a new antigenic A/H1N1pdm09 variant rather than from cross-reaction as a result of contact with previously circulating seasonal A/H1N1 variants. The immune responses against HA and NA were formed simultaneously right after natural infection with A/H1N1pdm09. NI antibodies correlated with virusneutralizing antibodies when acquired shortly after influenza infection. A group of middleaged patients with the lowest level of anti-NA antibodies against A/California/07/2009 (H1N1)pdm was identified, indicating the highest-priority vaccination against A/H1N1pdm09 viruses. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science | en_GB |
dc.title | Anti-neuraminidase antibodies against pandemic A/H1N1 influenza viruses in healthy and influenza-infected individuals | en_GB |
dc.type | Article | en_GB |
Располагается в коллекциях: | Articles |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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journal.pone.0196771.pdf | 2,64 MB | Adobe PDF | Просмотреть/Открыть |
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