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dc.contributor.authorDesheva, Yulia-
dc.contributor.authorSychev, Ivan-
dc.contributor.authorSmolonogina, Tatiana-
dc.contributor.authorRekstin, Andrey-
dc.contributor.authorIlyushina, Natalia-
dc.contributor.authorLugovtsev, Vladimir-
dc.contributor.authorSamsonova, Anastasia-
dc.contributor.authorGo, Aleksey-
dc.contributor.authorLerner, Anna-
dc.identifier.othereISSN 1932-6203-
dc.description.abstractThe main objective of the study was to evaluate neuraminidase inhibiting (NI) antibodies against A/H1N1pdm09 influenza viruses in the community as a whole and after infection. We evaluated NI serum antibodies against A/California/07/09(H1N1)pdm and A/South Africa/3626/2013(H1N1)pdm in 134 blood donors of different ages using enzyme-linked lectin assay and in 15 paired sera from convalescents with laboratory confirmed influenza. The neuraminidase (NA) proteins of both A/H1N1pdm09 viruses had minimal genetic divergence, but demonstrated different enzymatic and antigenic properties. 5.2% of individuals had NI antibody titers 1:20 against A/South Africa/3626/2013(H1N1)pdm compared to 53% of those who were positive to A/California/07/2009(H1N1)pdm NA. 2% of individuals had detectable NI titers against A/South Africa/3626/13(H1N1)pdm and 47.3% were positive to A/California/07/2009(H1N1)pdm NA among participants negative to hemagglutinin (HA) of A/H1N1pdm09 but positive to seasonal A/H1N1. The lowest NI antibody levels to both A/H1N1pdm09 viruses were detected in individuals born between 1956 and 1968. Our data suggest that NI antibodies against A/South Africa/3626/13 (H1N1)pdm found in the blood donors could have resulted from direct infection with a new antigenic A/H1N1pdm09 variant rather than from cross-reaction as a result of contact with previously circulating seasonal A/H1N1 variants. The immune responses against HA and NA were formed simultaneously right after natural infection with A/H1N1pdm09. NI antibodies correlated with virusneutralizing antibodies when acquired shortly after influenza infection. A group of middleaged patients with the lowest level of anti-NA antibodies against A/California/07/2009 (H1N1)pdm was identified, indicating the highest-priority vaccination against A/H1N1pdm09 viruses.en_GB
dc.publisherPublic Library of Scienceen_GB
dc.titleAnti-neuraminidase antibodies against pandemic A/H1N1 influenza viruses in healthy and influenza-infected individualsen_GB
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