Chapter 7. Mechanisms of antinoceptive response of a sensory neuron

Abstract

The seventh chapter is devoted to the determination of the mechanisms of changes in the dynamic complexity of the patterns of impulse activity of nociceptors. As a result of the study of the mechanisms of changes in the dynamic complexity of the patterns of impulse activity of nociceptive neurons when the antinociceptive response occurs, it was found that the change in this complexity is based on rearrangements in the temporal organization of patterns due to bifurcations of stationary states and limit cycles, leading to the appearance of two types of burst activity. The mechanism of correction of the damaging pain effect is based on the molecular mechanism of suppression of this activity associated with the modification of the activation gating structure of slow sodium NaV1.8 channels under the action of comenic acid, a drug substance of the non-opioid analgesic “Anoceptin”. The methodology for analyzing the considered molecular mechanism can be used in the search for new pharmacological targets for further research related to the development of innovative pharmacological strategies in the correction of pathological conditions.