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http://hdl.handle.net/11701/45568
Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Kazakova, Tatiana | - |
dc.contributor.author | Marshinskaya, Olga | - |
dc.contributor.author | Notova, Svetlana | - |
dc.date.accessioned | 2024-06-07T12:00:36Z | - |
dc.date.available | 2024-06-07T12:00:36Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.citation | Kazakova, T., Marshinskaya, O., and Notova, S. 2024. Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development. Bio. Comm. 69(1): 12–25. https://doi.org/10.21638/spbu03.2024.102 | en_GB |
dc.identifier.other | https://doi.org/10.21638/spbu03.2024.102 | - |
dc.identifier.uri | http://hdl.handle.net/11701/45568 | - |
dc.description.abstract | The study evaluated the effects of prenatal exposure to manganese (Mn) on the functional state of offspring at later stages of postnatal development (PND). Female rats were treated with MnSO4 · 5H2O in the diet at a dose of 1433 mg/kg starting 28 days prior to breeding and through gestation. The pregnancy proceeded normally, no physical abnormalities were observed. There was a lag in physical development of the offspring, which was characterized by a later opening of the eyes, the formation of a coat and the eruption of incisors, the weight gain was attenuated from PND 0–84. Offspring had hyperactive behavior and deterioration in spatial learning and memory. The level of Mn in the blood serum and cerebral cortex was higher than the control values by 11 and 53 % respectively. The acetylcholinesterase level in the serum was higher by 47 %. These findings highlight the risk of prenatal exposure to subchronic doses of Mn. | en_GB |
dc.description.sponsorship | The present work was prepared within the framework of the state task of the Federal Research Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences (project no. FNWZ-2022-0011). | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | St Petersburg State University | en_GB |
dc.relation.ispartofseries | Biological Сommunications;Volume 69; Issue 1 | - |
dc.subject | heavy metals | en_GB |
dc.subject | manganese | en_GB |
dc.subject | toxicity | en_GB |
dc.subject | prenatal influence | en_GB |
dc.subject | behavior | en_GB |
dc.subject | cognitive abilities | en_GB |
dc.subject | acetylcholinesterase | en_GB |
dc.subject | biomarker | en_GB |
dc.title | Influence of subchronic exposure to manganese carried by female rats during pregnancy on the behavioral and cognitive abilities of their offspring at later stages of postnatal development | en_GB |
dc.type | Article | en_GB |
Располагается в коллекциях: | Issue 1 |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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BioComm_69_1_12-25.pdf | 1,32 MB | Adobe PDF | Просмотреть/Открыть |
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