Review
 of scientific advisors of qualifying work of 5th course student 
Adamov Alexander Sergeevich

"Development of a synthesis method of fluoroalkyl-containing pirazolyl diazomethanes "

The aim of thesis of A. Adamov was to study the reactions of fluorinated diazodiketones with N, N- (dialkylamino) propyne and development on this basis of the method of synthesis of previously unknown fluoralkyl-containing pirazolyl diazomethanes, which are of great interest as precursors of biologically active substances.

The study found that the direction of the reactions of fluorinated diazodiketones and (dialkylamino) propynes is determined by structural factors: in the case of trifluoromethyl substituent, and (diethylamino) group observed [2 + 2] cycloaddition of carbonyl trifluoroacetyl group to the triple bond of propyne to give 4 - (trifluoromethyl) -substituted pyrazole, whereas in the presence in the structure of the starting compounds more bulky substituents such as heptafluoropropyl and (diisopropyl) amino realized [3 + 2] cycloaddition, resulting in the 3- (heptafluoro-acyl) substituted pyrazole.

It is also shown that 3-aryl substitued pyrazoles react readily with tosyl hydrazide giving high yields of hydrazones, interaction of which with sodium hydride under anhydrous conditions in the presence of triphenylphosphine as a "trap" aryl diazo compound yields phosphosines of pyrazolyl diazomethane.

In carrying out qualifying work, the student has mastered A. Adamov experimental research methods, techniques, separation of complex reaction mixtures by chromatography, working with unstable diazo compounds, learned to work with the scientific literature. However, due to the inability to allocate his full time and energy to it, unfortunately, was unable to fully implement the program of planned experimental research on his thesis.

We believe that proposed to defense diploma of student of the Department of Organic Chemistry, Alexander Adamov deserves rating of "good."

Supervisors
/V. A. Nikolaev/

/J.J Medvedev/