Review on the thesis "Synthesis of tetrazolyl analogs of natural amino acids" of Mukhametshina Anastasia Viktorovna, on the bachelor qualification The reviewed graduation qualification work of Mukhametshina A.V. is devoted to the synthesis and description of new tetrazolyl analogs of natural amino acids: L-ornithine, L-tyrosine and L-glutamic acid. Tetrazolyl analogs and derivatives of amino acids are perspective objects for medical chemistry. Recently the increasing attention of many research groups is paid to introduction of the tetrazolyl fragment into structure of natural amino acids for the purpose of creation of new biologically active agents. It is connected with unique properties of a tetrazolyl cycle, such as his bioizosterizm to carboxyl and amino groups, the high metabolic stability and high passability through biological barriers. In this regard, subject of qualification work of Mukhametshina A.V. is very actual. Graduation baccalaureate work of Mukhametshina A. V. consists of several main sections: introduction, literature review, experimental part as well as a section devoted to the discussion of the results, the conclusions of the work and a list of references that includes 70 references. In the literary review author discussed methods for obtaining of tetrazolyl analogs and derivatives of amino acids, as well as some aspects of their biological activity. In the experimental part Mukhametshina A. V. gives procedures for obtaining of tetrazolyl analogs of amino acids, including statement and removal of the protective groups. All obtained compounds have been characterized by modern physico-chemical methods (1H and 13C NMR spectroscopy, mass spectrometry of high resolution, a polarimetry). In conclusion of baccalaureate work the author gives valid conclusions. However it can be note the following drawbacks: - in the introduction the author writes that obtaining new tetrazolyl analogs of amino acids is the potential neurotransmitters. However from the literary review it is not clear why the replacement of the α-amino group in the case of L-tyrosine and L- glutamic acid and δ-amino groups in the L-ornithine on tetrazolyl fragment can lead to increased biological activity. Partly this defect is compensated by the data obtained during computer forecasting of biological activity. - the literary review has no name; - in the compound 14 (Scheme 4) in the literature review the mistake is made; - for a better understanding of the work it is necessary to formulate accurately the purpose and tasks of the research. However these shortcomings do not impair the positive impression from the qualifying work of Mukhametshina A.V. The work is performed methodically competently, meets all requirements to basic researches. The author of work has successfully coped with the purpose of the thesis and research problems. The level of the research and its practical significance allow to make the conclusion that final qualification work as Mukhametshina A.V. meets requirements imposed to baccalaureate works and deserves an assessment "excellent". Student Mukhametshina A.V. deserves the award of a bachelor's degree in the direction 020100 "Chemistry".   Junior researcher St. Petersburg State Institute of Technology (Technical University) Candidate of Chemistry                                                                      Yu.N. Pavlyukova