Review  for the final qualifying work  "Synthesis of  α-keto-δ-(NG,NG-dimethylguanidino)valeric acid – regulator NO-synthase activity" of 4th year student of the St. Petersburg State University, the Institute of Chemistry Marchenko Sergey Alexseevich  Thesis Marchenko S.A. is devoted to the actual topic - the development of a synthetic scheme for producing alpha-keto-δ- (NG, NG-dimethylguanidino) valeric acid (DMGV), which is a risk factor for cardiovascular zabolevaniy. In literature DMGV preparative synthesis is not described. At the same time, it samples required in the biochemical studies of nitric oxide (II) synthesis disorders. At present DMGV produced only enzymatically in small amounts. Therefore, before the author was important and actual synthetic problem.  As the direct synthetic precursor of the expected acid is asymmetric dimethylarginine (ADMA), the author analyzed the published data with known methods for preparing substituted arginine. The most problematic in terms of the synthesis fragment ADMA is a guanidine group. Therefore, it was considered several existing schemes produce exactly the guanidine fragment.  Based on analysis of the literature, was chosen the optimal scheme for ADMA based on the thiotcitruline, thiourea moiety which is converted to a guanidine under action of the EDCI and dimethylammonium salt of 1-hydroxybenzotriazole.  Using as starting compound ornithine was carried out by the author 11-step synthesis, which is the final target compound was isolated in high purity as confirmed by NMR-spectroscopy. Synthesis included obtaining protected by an ester group and the α-amino group of ornithine, then followed key obtaining step thiourea and its subsequent conversion into protected guanidine. At the final stage, after removal of all protecting groups α-amino group was converted to an oxo-group with the action of trifluoroacetic anhydride followed by hydrolysis.  Choice and realization of a synthetic scheme for obtaining the desired compound looks very convincing. The author has done a considerable synthetic and thorough work, mastered the methods of setting and removal of protecting groups, as well as methods of analysis and the identification allocated by the reaction products, such as HPLC, mass spectrometry and NMR spectroscopy.  At work there are the following questions: 1) The author writes to allocate dimethylarginine as hydrochloride while using HCl solution for 1 equivalent of thionyl chloride followed by treatment with 1 equivalent of acid, which is a diacid base. How it was established that it was obtained monohydrochloride?  2) In the appendix shows the spectra of a open-chain and cyclic forms of the resulting compound, however, is not discussed in the text of the work, how they were obtained. In some circumstances, there is one, and in any other form, and why?  In conclusion, it should be noted that the author has done a great job for the synthetic multi-step synthesis with the successful release of the final stage of the target compound. The text of the paper contains a number of typos and unsuccessful formulations that does not affect the good impression of the work as a whole. Operation is subject to and the volume and quality requirements of the final qualifying works. I believe that its author, Marchenko S.A., deserves evaluation "excellent".   Reviewer, Associate Professor, Department of Organic Chemistry federal state budgetary educational institutions of higher professional Education "Saint-Petersburg State University", Dr. by specialty 02.00.03 - organic chemistry                                                                       Dar'in D.V.